Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036632 | 0.81 | HSD11B1 (0.48) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL17188550 | 0.81 | HSD11B1 (0.48) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL6895298 | 0.81 | ALDH1A1 (0.54) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL12791867 | 0.76 | HSD11B1 (0.36) | HSD11B1SCN9A | |
| SCHEMBL12791748 | 0.76 | HSD11B1 (0.36) | HSD11B1SCN9A | |
| SCHEMBL18467244 | 0.73 | PRKCA (0.44) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL15432440 | 0.73 | LMNA (0.42) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL17050923 | 0.71 | HSD11B1 (0.39) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL2636721 | 0.71 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL12791827 | 0.71 | HSD11B1 (0.44) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438043-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141424-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |