Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 3/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740550 | 0.87 | HSD11B1 (0.48) | HSD11B1NPC1LMNATP53MAPT | |
| SCHEMBL19376023 | 0.81 | HSD11B1 (0.49) | HSD11B1NPC1LMNATP53MAPT | |
| SCHEMBL29138582 | 0.79 | HSD11B1 (0.61) | HSD11B1LMNATP53MAPTSMN1; SMN2 | |
| SCHEMBL25431355 | 0.76 | HSD11B1 (0.39) | HSD11B1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL28543260 | 0.75 | CCNK (0.60) | — | |
| SCHEMBL28543261 | 0.75 | CCNK (0.60) | — | |
| SCHEMBL28552948 | 0.75 | CCNK (0.60) | — | |
| SCHEMBL4958586 | 0.74 | NPC1 (0.62) | HSD11B1NPC1LMNATP53MAPT | |
| SCHEMBL829518 | 0.74 | SPR (0.51) | HSD11B1NPC1LMNATP53MAPT | |
| SCHEMBL31622418 | 0.74 | HSD11B1 (0.39) | HSD11B1SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438043-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141424-A1 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |