Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 2/20 | 0.37 |
| ▸ | ALPG | P10696 | 2/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637249 | 0.89 | SMN1; SMN2 (0.50) | ALDH1A1KMT2AHPGDKDM4ETSHR | |
| SCHEMBL2637908 | 0.84 | NPC1 (0.45) | ALDH1A1KMT2AKDM4EMEN1USP2 | |
| SCHEMBL2638043 | 0.83 | MAPK10 (0.45) | KMT2AMEN1GAAADORA2AADORA2B | |
| SCHEMBL2637445 | 0.83 | NPC1 (0.38) | ALDH1A1KMT2AHPGDKDM4EMEN1 | |
| SCHEMBL2637520 | 0.80 | DHODH (0.45) | KMT2AKDM4EMEN1ALPLALPI | |
| SCHEMBL2637592 | 0.79 | MEN1 (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL2637918 | 0.79 | KMT2A (0.41) | ALDH1A1KMT2AKDM4EMEN1MAPK1 | |
| SCHEMBL2637500 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KMT2AHPGDKDM4EMEN1 | |
| SCHEMBL2637350 | 0.78 | ERCC1 (0.48) | ALDH1A1KMT2AHPGDKDM4ETSHR | |
| SCHEMBL2637204 | 0.78 | NPC1 (0.43) | ALDH1A1KMT2AMEN1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |