SCHEMBL263726

SCHEMBL263726

CN(C)c1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 7/20 0.75
IMPDH1 P20839 2/20 0.75
TAS1R3 Q7RTX0 3/20 0.72
TAS1R1 Q7RTX1 3/20 0.72
NT5E P21589 1/20 0.63
CA5A P35218 1/20 0.60
TGM2 P21980 1/20 0.58
DNPH1 O43598 1/20 0.58
PRKAB2 O43741 1/20 0.58
TRPM2 O94759 1/20 0.58
LDHA P00338 1/20 0.58
ADRB2 P07550 1/20 0.58
FBP1 P09467 1/20 0.58
SRC P12931 1/20 0.58
ADORA1 P30542 1/20 0.58
P2RY2 P41231 1/20 0.58
P2RY1 P47900 1/20 0.58
PRKAG1 P54619 1/20 0.58
PRKAA2 P54646 1/20 0.58
PDE4D Q08499 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16508951 0.93 IMPDH2 (0.66) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL30363045 0.92 P2RX3 (0.65) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL14946399 0.92 P2RX3 (0.65) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL18574074 0.92 P2RX3 (0.65) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL14929515 0.92 P2RX3 (0.65) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL18574075 0.92 IMPDH2 (0.64) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL14946391 0.92 IMPDH2 (0.64) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL14929355 0.92 IMPDH2 (0.64) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL15930974 0.88 IMPDH2 (0.79) IMPDH2IMPDH1TAS1R3TAS1R1NT5E
SCHEMBL113725 0.87 IMPDH2 (0.60) IMPDH2IMPDH1TAS1R3TAS1R1NT5E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE TEAM MEDICAL, LLC 2025-09-18 US disclosed
WO-2021064421-A1 TREATMENT OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2021-04-08 WO disclosed
US-8841422-B2 Human androgen receptor alternative splice variants UNIVERSITY OF MARYLAND, BALTIMORE (US) 2014-09-23 US disclosed
US-20120156770-A1 HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS UNIVERSITY OF MARYLAND, BALTIMORE (US) 2012-06-21 US disclosed
US-8133724-B2 Human androgen receptor alternative splice variants as biomarkers and therapeutic targets UNIVERSITY OF MARYLAND, BALTIMORE (US) 2012-03-13 US disclosed
US-20100068802-A1 NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETS UNIVERSITY OF MARYLAND, BALTIMORE (US) 2010-03-18 US disclosed
US-7368551-B2 Comprises nucleotide sequence coding methyltransferase for use as tool in diagosing tumor disorders THE GENERAL HOSPITAL CORPORATION (US) 2008-05-06 US disclosed
US-20040234997-A1 De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof THE GENERAL HOSPITAL CORPORATION 2004-11-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE SYNCRIP, SNRPA, RNASE1 IMPDH2 2469/4885IMPDH1 2279/4885TAS1R3 3879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.