Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637207 | 0.82 | CNR2 (0.45) | NPC1RAB9ACNR2MAPTMEN1 | |
| SCHEMBL2637666 | 0.80 | POLB (0.43) | NPC1RAB9ACNR2MEN1KMT2A | |
| SCHEMBL2637448 | 0.79 | NPC1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4A | |
| SCHEMBL2637450 | 0.79 | MEN1 (0.38) | NPC1RAB9ACNR2MEN1KMT2A | |
| SCHEMBL2637249 | 0.79 | SMN1; SMN2 (0.50) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL2637260 | 0.79 | CNR2 (0.50) | NPC1RAB9ACNR2MEN1KMT2A | |
| SCHEMBL2637493 | 0.78 | NHERF1 (0.46) | NPC1RAB9ACNR2MAPTL3MBTL1 | |
| SCHEMBL2637188 | 0.77 | MGAM (0.50) | NPC1RAB9AMAPTL3MBTL1MEN1 | |
| SCHEMBL2637531 | 0.76 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL2638320 | 0.76 | DHPS (0.46) | NPC1RAB9AMEN1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |