Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.95 |
| ▸ | PNP | P00491 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 2/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.45 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hypoxanthine SCHEMBL25381 | 0.97 | ALDH1A1 (1.00) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL7037918 | 0.97 | ALDH1A1 (1.00) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL30096461 | 0.97 | ALDH1A1 (1.00) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL122843 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL28386541 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL30605050 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL7168422 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL560392 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL29515776 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A | |
| Hypoxanthine SCHEMBL28774651 | 0.95 | ALDH1A1 (0.95) | ALDH1A1PNPPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670809-B1 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | MAYNE PHARMA PLC (GB) | 2016-01-13 | — | — | EP | claimed |
| JP-4830128-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| EP-1670809-A2 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | SuperGen, Inc. (US) | 2006-06-21 | — | — | EP | claimed |
| US-20050267056-A1 | Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives | MAYNE PHARMA (USA) INC. | 2005-12-01 | — | — | US | claimed |
| WO-2005027838-A2 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | SUPERGEN, INC. (US) | 2005-03-31 | — | — | WO | claimed |
| CN-108680630-A | A kind of directly double enzyme electrodes and its application in phytase activity measurement | 山东省科学院生物研究所 | 2018-10-19 | — | — | CN | disclosed |
| EP-1670809-B1 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | MAYNE PHARMA PLC (GB) | 2016-01-13 | — | — | EP | disclosed |
| EP-1670809-A2 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | SuperGen, Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050267056-A1 | Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives | MAYNE PHARMA (USA) INC. | 2005-12-01 | — | — | US | disclosed |
| WO-2005027838-A2 | SYNTHESIS AND MANUFACTURE OF PENTOSTATIN AND ITS PRECURSORS, ANALOGS AND DERIVATIVES | SUPERGEN, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267056-A1 | Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives | UMPS, THPO, DHPS | ALDH1A1 2644/4885PNP 31/4885PI4KA 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.