Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394035 | 0.85 | LRRK2 (0.44) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL26394712 | 0.82 | GSK3B (0.51) | CYP1A2CYP3A4CLK4CYP2C19CYP2D6 | |
| SCHEMBL26394420 | 0.80 | JAK2 (0.66) | CYP1A2CYP3A4HSD17B10CLK4MAPK1 | |
| SCHEMBL26394054 | 0.79 | CDK7 (0.46) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL26393847 | 0.79 | MAP2K4 (0.41) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL25419245 | 0.77 | TRPA1 (0.52) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL31472533 | 0.77 | TRPA1 (0.52) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 | |
| SCHEMBL26393692 | 0.77 | GSK3B (0.41) | CLK4LRRK2GSK3BPLK4MAPK13 | |
| SCHEMBL26396309 | 0.77 | LRRK2 (0.45) | CLK4LRRK2JAK2JAK1TYK2 | |
| SCHEMBL26395345 | 0.76 | LRRK2 (0.42) | CYP1A2CYP3A4ALDH1A1HSD17B10CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |