Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 4/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394035 | 0.87 | LRRK2 (0.44) | LRRK2ABCC9CDK8CCNCCDC7 | |
| SCHEMBL26397024 | 0.86 | LRRK2 (0.41) | LRRK2JAK3JAK2JAK1TYK2 | |
| SCHEMBL26393692 | 0.86 | GSK3B (0.41) | LRRK2ABCC9CDK8CCNCCDC7 | |
| SCHEMBL26396791 | 0.85 | GSK3B (0.47) | LRRK2JAK3JAK2TYK2CDK8 | |
| SCHEMBL26393486 | 0.84 | HDAC6 (0.50) | JAK3JAK2JAK1TYK2CDK8 | |
| SCHEMBL26396381 | 0.80 | GSK3B (0.40) | JAK3CDK8CDC7PAK1DAPK3 | |
| SCHEMBL26394420 | 0.80 | JAK2 (0.66) | JAK3JAK2JAK1TYK2CDK8 | |
| SCHEMBL26394340 | 0.79 | GSK3B (0.47) | JAK3JAK2JAK1TYK2CDK8 | |
| SCHEMBL26395039 | 0.77 | HDAC6 (0.47) | JAK3JAK2JAK1TYK2CDK8 | |
| SCHEMBL26394366 | 0.77 | CYP1A2 (0.59) | LRRK2JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |