Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26393486 | 0.84 | HDAC6 (0.50) | GSK3BPAK1CYP1A2JAK2JAK1 | |
| SCHEMBL26394395 | 0.83 | MAP2K4 (0.55) | GSK3BMAP2K4JAK2TYK2JAK3 | |
| SCHEMBL26394420 | 0.80 | JAK2 (0.66) | GSK3BPRKAA1PAK1CYP1A2JAK2 | |
| SCHEMBL26395039 | 0.79 | HDAC6 (0.47) | GSK3BPRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL26396309 | 0.79 | LRRK2 (0.45) | GSK3BPAK1JAK2JAK1TYK2 | |
| SCHEMBL26131696 | 0.78 | ABL1 (0.50) | GSK3BPRKAA1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL26394712 | 0.74 | GSK3B (0.51) | GSK3BPRKAA1PAK1CYP1A2JAK2 | |
| SCHEMBL26394241 | 0.73 | HDAC6 (0.48) | GSK3BPRKAA1PAK1JAK2JAK1 | |
| SCHEMBL12064447 | 0.70 | NTRK1 (0.47) | GSK3BCDK2GSK3A | |
| SCHEMBL5773496 | 0.70 | FADS1 (0.60) | GSK3BCDK8CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |