Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26393692 | 0.78 | GSK3B (0.41) | LRRK2CDK8CLK4GSK3BPLK4 | |
| SCHEMBL31243437 | 0.77 | DYRK1A (0.48) | GSK3BPIM1CDK2DYRK1AGSK3A | |
| SCHEMBL26129618 | 0.77 | DYRK1A (0.48) | GSK3BPIM1CDK2DYRK1AGSK3A | |
| SCHEMBL26395413 | 0.77 | DYRK1A (0.43) | CDK8CLK4GSK3BPLK4MAPK13 | |
| SCHEMBL26394284 | 0.76 | CDK8 (0.46) | CDK8CLK4GSK3BPLK4MAPK13 | |
| SCHEMBL26394035 | 0.76 | LRRK2 (0.44) | LRRK2CDK8CLK4CCNCALDH1A1 | |
| SCHEMBL26394366 | 0.76 | CYP1A2 (0.59) | LRRK2CDK8CLK4GSK3BPLK4 | |
| SCHEMBL26396737 | 0.75 | PIM1 (0.45) | CDK8CLK4GSK3BPLK4MAPK13 | |
| SCHEMBL26394241 | 0.70 | HDAC6 (0.48) | CDK8CLK4GSK3BPLK4MAPK13 | |
| SCHEMBL2431672 | 0.69 | FADS1 (0.55) | GSK3BMAPK1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |