SCHEMBL2639683

SCHEMBL2639683

COc1ccc(CC(=O)Nc2ccccc2)cc1Oc1cc(Cl)cc(C#N)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 3/20 0.52
ACHE P22303 3/20 0.52
MAPT P10636 6/20 0.51
ALDH1A1 P00352 5/20 0.51
HSD17B10 Q99714 3/20 0.51
KDM4E B2RXH2 3/20 0.51
HPGD P15428 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
POLB P06746 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
EPHX2 P34913 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.49
LMNA P02545 4/20 0.49
HTT P42858 3/20 0.49
KMT2A Q03164 3/20 0.49
TSHR P16473 2/20 0.49
MAPK1 P28482 2/20 0.49
MEN1 O00255 2/20 0.49
USP2 O75604 1/20 0.49
ALOX15 P16050 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2638916 0.89 P2RX7 (0.53) MAPTALDH1A1HSD17B10KDM4EHPGD
SCHEMBL2638227 0.89 LMNA (0.46) BCHEACHEMAPTALDH1A1HSD17B10
SCHEMBL2639938 0.87 CA1 (0.53) POLBEPHX2KMT2A
SCHEMBL2638078 0.84 LMNA (0.51) BCHEACHEMAPTALDH1A1HSD17B10
SCHEMBL4602268 0.84 CA1 (0.53) POLBEPHX2KMT2A
SCHEMBL4603571 0.84 EPHX2 (0.48) BCHEACHEMAPTALDH1A1HSD17B10
SCHEMBL13492251 0.82 SMN1; SMN2 (0.48) MAPTALDH1A1HSD17B10KDM4EHPGD
SCHEMBL4986354 0.81 P2RX7 (0.43) MAPTALDH1A1HSD17B10KDM4EHPGD
SCHEMBL2638536 0.80 CA1 (0.60) MAPTSMN1; SMN2
SCHEMBL13586555 0.80 RORC (0.42) MAPTALDH1A1POLBEPHX2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4810529-B2 2011-11-09 JP claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed
EP-1742908-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-17 EP claimed
WO-2005102989-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-11-03 WO claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP disclosed