SCHEMBL2640221

SCHEMBL2640221

CCCC(=O)NS(=O)(=O)Oc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
ALOX5 P09917 1/20 0.46
TP53 P04637 1/20 0.44
MTNR1B P49286 4/20 0.44
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
HPGD P15428 1/20 0.44
CYP2C19 P33261 2/20 0.43
RECQL P46063 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
CYP3A4 P08684 1/20 0.42
STS P08842 1/20 0.42
MAPK1 P28482 1/20 0.41
MTNR1A P48039 2/20 0.41
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27538963 0.87 KMT2A (0.58) MEN1KMT2ATP53ALDH1A1CYP2C19
SCHEMBL7532809 0.83 KMT2A (0.62) MEN1KMT2ATP53MTNR1BALDH1A1
SCHEMBL28232247 0.81 KMT2A (0.64) MEN1KMT2ATP53MAPTSTS
SCHEMBL15424553 0.78 MEN1 (0.68) MEN1KMT2ATP53MTNR1BALDH1A1
SCHEMBL9451255 0.77 MEN1 (0.58) MEN1KMT2ATP53ALDH1A1MAPT
SCHEMBL7111521 0.77 KMT2A (0.72) MEN1KMT2ATP53STSHTT
SCHEMBL2810873 0.75 EPHX2 (0.55) ALOX5ALDH1A1HPGDKDM4EGAA
SCHEMBL728970 0.74 KMT2A (1.00) MEN1KMT2ATP53STS
SCHEMBL7744231 0.74 CASP1 (0.51) MTNR1BL3MBTL1POLBATM
Hydrochloric Acid SCHEMBL5124029 0.73 EPHX2 (0.54) ALOX5ALDH1A1HPGDKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4745228-B2 2011-08-10 JP claimed
US-20060247327-A1 Dental composition comprising ethylene imine compounds and non-reactive accelerators 3M HEALTHCARE GERMANY GMBH (DE) 2006-11-02 US claimed
EP-1498099-B1 Dental composition comprising ethylene imine compounds an non-reactive accelerators 3M ESPE AG (DE) 2005-03-23 EP claimed
WO-2005013924-A1 DENTAL COMPOSITION COMPRISING ETHYLENE IMINE COMPOUNDS AND NON-REACTIVE ACCELERATORS 3M ESPE AG (DE) 2005-02-17 WO claimed
EP-1498099-A1 Dental composition comprising ethylene imine compounds an non-reactive accelerators 3M Espe AG (DE) 2005-01-19 EP claimed
EP-3497164-A1 BLOCKED POLYURETHANE IMPACT MODIFIERS FOR IMPROVING THE IMPACT STRENGTH OF LOW-TEMPERATURE CURING SINGLE-COMPONENT EPOXY ADHESIVES Sika Technology AG (CH) 2019-06-19 EP disclosed
US-7838572-B2 Dental composition comprising ethylene imine compounds and non-reactive accelerators 3M INNOVATIVE PROPERTIES COMPANY (US) 2010-11-23 US disclosed
US-20060247327-A1 Dental composition comprising ethylene imine compounds and non-reactive accelerators 3M HEALTHCARE GERMANY GMBH (DE) 2006-11-02 US disclosed
EP-1498099-B1 Dental composition comprising ethylene imine compounds an non-reactive accelerators 3M ESPE AG (DE) 2005-03-23 EP disclosed
WO-2005013924-A1 DENTAL COMPOSITION COMPRISING ETHYLENE IMINE COMPOUNDS AND NON-REACTIVE ACCELERATORS 3M ESPE AG (DE) 2005-02-17 WO disclosed
EP-1498099-A1 Dental composition comprising ethylene imine compounds an non-reactive accelerators 3M Espe AG (DE) 2005-01-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060247327-A1 Dental composition comprising ethylene imine compounds and non-reactive accelerators TAS1R1, TAS2R30, TAS2R39 MEN1 3618/4885KMT2A 2348/4885ALOX5 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.