TAS1R1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL95611	0.63	13/20
SCHEMBL200816	0.63	9/20
SCHEMBL245758	0.54	9/20
SCHEMBL165896	0.54	9/20
SCHEMBL178910	0.53	8/20
SCHEMBL108094	0.52	8/20
SCHEMBL139991	0.52	8/20
SCHEMBL201947	0.69	7/20
Siduron (SCHEMBL66323)	0.66	7/20
SCHEMBL201362	0.65	7/20
SCHEMBL162688	0.62	7/20
3,6 Dichloromethoxybenzoic Acid (SCHEMBL18336)	0.51	7/20
SCHEMBL108186	0.47	7/20
SCHEMBL203603	0.67	6/20
SCHEMBL203604	0.67	6/20
SCHEMBL40230	0.65	6/20
SCHEMBL44779	0.65	6/20
SCHEMBL44802	0.65	6/20
SCHEMBL44803	0.65	6/20
SCHEMBL201891	0.63	6/20

Clinical trials — most relevant to TAS1R1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Metabolic Effects of Non-Nutritive Sweeteners	PHASE1/PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Study of Taste Deficits	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
Genetic Variability in Taste Perception	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents	nan	NOT_YET_RECRUITING
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior	nan	COMPLETED
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN
Astringency and Oral Health	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TAS1R1 binder may also engage these)

Protein	Name	Similarity
Q923K1	—	1.000	Q923K1 →
Q99PG6	—	1.000	Q99PG6 →
Q9Z0R8	—	0.999	Q9Z0R8 →
Q49HH9	—	0.997	Q49HH9 →
Q717C1	—	0.996	Q717C1 →
Q717C2	—	0.996	Q717C2 →
Q925D8	—	0.996	Q925D8 →
Q49HI0	—	0.994	Q49HI0 →
A3QNZ8	—	0.993	A3QNZ8 →
TAS1R3	Taste receptor type 1 member 3	0.992	landscape →
A3QP00	—	0.992	A3QP00 →
Q49KI5	—	0.992	Q49KI5 →
A3QP09	—	0.991	A3QP09 →
A3QP07	—	0.990	A3QP07 →
A3QNZ9	—	0.990	A3QNZ9 →
TAS1R2	Taste receptor type 1 member 2	0.989	landscape →
Q925I4	—	0.987	Q925I4 →
A3QP01	—	0.987	A3QP01 →
A3QP08	—	0.986	A3QP08 →
Q9Z0R7	—	0.985	Q9Z0R7 →
P51839	—	0.974	P51839 →
Q6TAC4	—	0.972	Q6TAC4 →
O70410	—	0.972	O70410 →
Q70VB1	—	0.972	Q70VB1 →
P11688	—	0.970	P11688 →
Q8K4Z6	—	0.969	Q8K4Z6 →
ITGAL	Integrin alpha-L	0.969	landscape →
ITGA5	Integrin alpha-5	0.969	landscape →
O75578	—	0.968	O75578 →
Q13444	—	0.968	Q13444 →