Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 11/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185048 | 0.81 | BCHE (0.43) | MAPTALDH1A1SYKKDM4ELMNA | |
| SCHEMBL12615103 | 0.81 | BCHE (0.43) | MAPTALDH1A1SYKKDM4ELMNA | |
| SCHEMBL7905968 | 0.76 | CHRNB1 (0.43) | — | |
| SCHEMBL12486555 | 0.75 | MAPT (0.40) | HPGDMAPTALDH1A1HIF1APSEN1 | |
| SCHEMBL4580268 | 0.74 | NUDT1 (0.46) | HPGDMAPTALDH1A1PSEN1PSEN2 | |
| SCHEMBL83400 | 0.73 | CUL4A (0.38) | HPGDMAPTALDH1A1HIF1APSEN1 | |
| SCHEMBL16792885 | 0.73 | MAPT (0.40) | HPGDMAPTALDH1A1HIF1APSEN1 | |
| SCHEMBL9893169 | 0.71 | FFAR1 (0.46) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1331448 | 0.71 | METAP2 (0.62) | NOS2 | |
| SCHEMBL1331859 | 0.71 | METAP2 (0.62) | NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600874-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | Amgen, Inc (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2011143033-A1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |