Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26408251 | 0.97 | CACNA1H (0.43) | CACNA1HLMNAMAPTACKR3MGLL | |
| SCHEMBL26409305 | 0.87 | CACNA1H (0.42) | CACNA1HLMNAMAPTACKR3MGLL | |
| SCHEMBL26408706 | 0.86 | CACNA1H (0.36) | CACNA1HMGLL | |
| SCHEMBL26407859 | 0.85 | CACNA1H (0.56) | CACNA1HLMNAMAPTACKR3MGLL | |
| SCHEMBL26408705 | 0.85 | NPSR1 (0.40) | CACNA1HLMNAACKR3ALDH1A1KDM4E | |
| SCHEMBL26408695 | 0.84 | SMN1; SMN2 (0.48) | MAPTMGLLALDH1A1KDM4ETP53 | |
| SCHEMBL26408044 | 0.83 | CACNA1H (0.48) | CACNA1HMGLLALDH1A1MEN1KMT2A | |
| SCHEMBL26408443 | 0.81 | ACKR3 (0.40) | CACNA1HLMNAMAPTACKR3MGLL | |
| SCHEMBL26408937 | 0.80 | HRH2 (0.40) | CACNA1HLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL26411550 | 0.79 | CACNA1H (0.42) | CACNA1HMGLLALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192675-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |