Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948366 | 0.96 | LMNA (0.47) | LMNATHRBHSD17B3DHODHTP53 | |
| SCHEMBL1948851 | 0.96 | NOTUM (0.44) | LMNATHRBHSD17B3DHODHTP53 | |
| SCHEMBL18669071 | 0.82 | ALDH1A1 (0.44) | LMNAHSD17B3HDAC6DRD2MAPT | |
| SCHEMBL1948510 | 0.81 | NOTUM (0.64) | LMNATHRBHSD17B3TP53HSP90AA1 | |
| SCHEMBL1950239 | 0.81 | NOTUM (0.64) | LMNATHRBHSD17B3TP53DRD2 | |
| SCHEMBL1948364 | 0.81 | ESR2 (0.60) | LMNAHSD17B3TP53HTTSMN1; SMN2 | |
| SCHEMBL12359781 | 0.80 | CHRM4 (0.49) | DRD2CHRM4HTR7AVPR2 | |
| SCHEMBL1948375 | 0.80 | DRD2 (0.51) | LMNATHRBHSD17B3DRD2POLB | |
| SCHEMBL1950469 | 0.80 | DRD4 (0.50) | LMNATHRBTP53HSP90AA1HDAC8 | |
| SCHEMBL27975558 | 0.79 | NOTUM (0.65) | HSD17B3DHODHTRIM24NOTUMAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |