Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26414144 | 0.85 | CCR5 (0.39) | LRRK2NPBWR1MCHR1KDM4EALDH1A1 | |
| SCHEMBL23663321 | 0.80 | ABCB1 (0.40) | NPBWR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL29965617 | 0.80 | ABCB1 (0.40) | NPBWR1KDM4EALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL29965303 | 0.79 | ACLY (0.46) | LRRK2KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23663283 | 0.79 | ACLY (0.46) | LRRK2KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29965223 | 0.77 | MAPT (0.39) | NPBWR1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL23663272 | 0.77 | MAPT (0.39) | NPBWR1CYP1A2CYP2C9CYP2C19LMNA | |
| SCHEMBL23663222 | 0.74 | CCR5 (0.42) | LRRK2NPBWR1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL26402718 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1LMNARAB9ACCR5 | |
| SCHEMBL23663346 | 0.73 | MAPK14 (0.40) | KDM4EALDH1A1CCR5MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | TSHR, THRA, THRB | LRRK2 1521/4885NPBWR1 154/4885MCHR1 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.