Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050758 | 0.78 | P2RX7 (0.42) | SLC6A2SLC6A4P2RX7 | |
| SCHEMBL17080539 | 0.78 | HDAC6 (0.33) | HDAC6SLC6A2SLC6A4KDM4CP2RX7 | |
| SCHEMBL17080583 | 0.78 | SLC6A2 (0.33) | SLC6A2SLC6A4KDM4CP2RX7ICAM1 | |
| SCHEMBL20489398 | 0.77 | NOS3 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL17298724 | 0.75 | NOS3 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31480992 | 0.74 | ALDH1A1 (0.45) | SLC6A2SLC6A4ALDH1A1MAOAMAOB | |
| SCHEMBL23361675 | 0.72 | NOS3 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL21949396 | 0.72 | ALOX5AP (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29739395 | 0.71 | NOS3 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL24737534 | 0.71 | NOS3 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49687-E1 | Thienopyrimidine and thienopyridine compounds and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-10-10 | — | — | US | disclosed |