Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 9/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26134353 | 0.81 | ALKBH1 (0.36) | LMNAPOLBADORA3ALDH1A1ADORA2A | |
| SCHEMBL26425747 | 0.81 | NPC1 (0.43) | LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL7510794 | 0.77 | PDE10A (0.41) | LMNAPOLBPDE10AADORA3ALDH1A1 | |
| SCHEMBL26134260 | 0.77 | TEAD2 (0.43) | ADORA3ALDH1A1KDM4EADORA2AADORA1 | |
| SCHEMBL26405871 | 0.77 | CASP1 (0.33) | ALDH1A1 | |
| SCHEMBL7979529 | 0.76 | GAA (0.46) | LMNAPOLBADORA3ALDH1A1ADORA2A | |
| SCHEMBL7510800 | 0.73 | PDE10A (0.42) | PDE10AADORA3ALDH1A1KDM4EADORA2A | |
| SCHEMBL26051305 | 0.71 | AR (0.40) | PDE10AADORA2AADORA1 | |
| SCHEMBL26419959 | 0.70 | KLKB1 (0.43) | LMNAPOLBADORA3ALDH1A1KDM4E | |
| SCHEMBL7517096 | 0.70 | L3MBTL1 (0.46) | LMNAPOLBPDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |