Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | F9 | P00740 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20627049 | 0.88 | AURKA (0.50) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL19915930 | 0.79 | FGFR1 (0.62) | ALDH1A1KDRFGFR1 | |
| SCHEMBL2646769 | 0.79 | HTT (0.59) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL2642078 | 0.78 | FGFR1 (0.63) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL2642011 | 0.78 | HPGD (0.52) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL2666380 | 0.78 | HPGD (0.52) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL2641968 | 0.76 | NPC1 (0.62) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL1356729 | 0.76 | FGFR1 (0.66) | HPGDALDH1A1AURKAKDRAURKB | |
| SCHEMBL2641853 | 0.76 | FGFR1 (0.65) | HPGDALDH1A1KDRFGFR1SMN1; SMN2 | |
| SCHEMBL2641981 | 0.74 | FGFR1 (0.56) | HPGDALDH1A1AURKAKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563001-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | disclosed |
| US-5360809-A | Imidazole compounds and their use as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-11-01 | — | — | US | disclosed |
| EP-0563001-A1 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-29 | — | — | EP | disclosed |