Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 11/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27896185 | 0.83 | PLA2G10 (0.57) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL7134591 | 0.82 | PLA2G10 (0.83) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL8867699 | 0.81 | PLA2G10 (0.55) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| Terephthalamide SCHEMBL23774 | 0.81 | PARP1 (0.71) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL509167 | 0.80 | LOXL2 (0.60) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| Terephthalamide SCHEMBL3444098 | 0.80 | LOXL2 (0.60) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL873232 | 0.80 | PRSS1 (0.60) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| Terephthalamide SCHEMBL8931235 | 0.78 | PARP1 (0.60) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL4134122 | 0.78 | CA2 (0.64) | PLA2G10PLA2G2APARP10PARP1PARP4 | |
| SCHEMBL1268001 | 0.78 | PLA2G10 (0.57) | PLA2G10PLA2G2APARP10PARP1PARP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102690269-B | Trifluoro methyl substituted quinoline or quinoxaline compound and preparation method thereof, and pharmaceutical composition containing the compound and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2015-01-07 | — | — | CN | claimed |
| CN-102690269-A | Trifluoro methyl substituted quinoline or quinoxaline compound and preparation method thereof, and pharmaceutical composition containing the compound and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2012-09-26 | — | — | CN | claimed |
| CN-101993416-A | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2011-03-30 | — | — | CN | claimed |
| CN-109715632-A | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-102690269-B | Trifluoro methyl substituted quinoline or quinoxaline compound and preparation method thereof, and pharmaceutical composition containing the compound and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2015-01-07 | — | — | CN | disclosed |
| CN-101993416-B | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2013-09-11 | — | — | CN | disclosed |
| CN-102690269-A | Trifluoro methyl substituted quinoline or quinoxaline compound and preparation method thereof, and pharmaceutical composition containing the compound and purpose thereof | SHANGHAI INST MATERIA MEDICA | 2012-09-26 | — | — | CN | disclosed |
| CN-101993416-A | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2011-03-30 | — | — | CN | disclosed |
| US-7199140-B2 | Vinyl phenyl derivatives as GLK activators | ASTRAZENECA AB (SE) | 2007-04-03 | — | — | US | disclosed |
| EP-1406620-B1 | VINYL PHENYL DERIVATIVES AS GLK ACTIVATORS | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | US | disclosed |
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |
| US-5049665-A | Cephalosporin derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-09-17 | — | — | US | disclosed |
| US-4918070-A | Antibiotics | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| EP-0280240-A2 | Cephalosporin derivatives, process for their preparation and antibacterial agents | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-08-31 | — | — | EP | disclosed |
| US-4701452-A | STIMULANTS; ANTIBIOTICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | disclosed |
| EP-0152860-A2 | Use of cephalosporin compounds for the manufacture of a medicament for the modulation of the immunologic system | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-08-28 | — | — | EP | disclosed |
| US-4454129-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-06-12 | — | — | US | disclosed |
| EP-0064256-A2 | Cephalosporin derivatives and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054715-A1 | Vinyl phenyl derivatives as glk activators | GCK, GCKR, GK | PLA2G10 2030/4885PLA2G2A 1829/4885PARP10 2666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.