SCHEMBL873232

SCHEMBL873232

NC(=O)c1ccc(CO)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRSS1 P07477 2/20 0.60
PRSS2 P07478 1/20 0.60
PRSS3 P35030 1/20 0.60
PLA2G10 O15496 1/20 0.59
PLA2G2A P14555 1/20 0.59
PARP10 Q53GL7 9/20 0.55
PARP1 P09874 3/20 0.50
PARP4 Q9UKK3 2/20 0.50
TSHR P16473 2/20 0.50
ALDH1A1 P00352 1/20 0.50
KMT2A Q03164 1/20 0.50
PARP15 Q460N3 1/20 0.50
PARP14 Q460N5 1/20 0.50
PARP16 Q8N5Y8 1/20 0.50
PARP11 Q9NR21 1/20 0.50
POLB P06746 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAPT P10636 1/20 0.50
CYP2C19 P33261 1/20 0.50
RECQL P46063 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7134591 0.82 PLA2G10 (0.83) PLA2G10PLA2G2APARP10PARP1PARP4
Terephthalamide SCHEMBL27383156 0.81 PARP1 (0.57) PLA2G10PLA2G2APARP10PARP1PARP4
SCHEMBL10789197 0.81 PRSS1 (0.56) PRSS1PRSS2PRSS3PLA2G10PLA2G2A
SCHEMBL2633786 0.81 PLA2G10 (0.55) PLA2G10PLA2G2APARP10PARP1PARP4
Terephthalamide SCHEMBL23774 0.81 PARP1 (0.71) PLA2G10PLA2G2APARP10PARP1PARP4
Terephthalamide SCHEMBL3444098 0.80 LOXL2 (0.60) PLA2G10PLA2G2APARP10PARP1PARP4
SCHEMBL2642291 0.80 PLA2G10 (0.59) PLA2G10PLA2G2APARP10PARP1PARP4
SCHEMBL9863735 0.80 PRSS1 (0.48) PRSS1PRSS2PRSS3PLA2G10PLA2G2A
SCHEMBL25900916 0.80 PRSS1 (0.48) PRSS1PRSS2PRSS3PLA2G10PLA2G2A
SCHEMBL509167 0.80 LOXL2 (0.60) PLA2G10PLA2G2APARP10PARP1PARP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2612845-B1 AROMATIC COMPOUND CONTAINING SPECIFIC BRANCH AJINOMOTO KK (JP) 2020-08-05 EP claimed
US-10711033-B2 Branched chain-containing aromatic compound AJINOMOTO CO., INC. (JP) 2020-07-14 US claimed
EP-2643000-A2 THERAPEUTIC PIPERAZINES Dart Neuroscience (Cayman) Ltd (KY) 2013-10-02 EP claimed
EP-2612845-A1 AROMATIC COMPOUND CONTAINING SPECIFIC BRANCH Ajinomoto Co., Inc. (JP) 2013-07-10 EP claimed
WO-2012040258-A2 THERAPEUTIC PIPERAZINES HELICON THERAPEUTICS, INC. (US) 2012-03-29 WO claimed
US-20110065691-A1 THERAPEUTIC PIPERAZINES DART NEUROSCIENCE (CAYMAN) LTD. (KY) 2011-03-17 US claimed
EP-2001448-A2 FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE Cadbury Adams USA LLC (US) 2008-12-17 EP claimed
US-20080176945-A1 Carboxilic Acid Amides Provoking A Cooling Sensation GIVAUDAN SA (CH) 2008-07-24 US claimed
CN-101132833-A Carboxylic acid amides giving a cooling sensation GIVAUDAN SA (CH) 2008-02-27 CN claimed
EP-1853353-A2 CARBOXYLIC ACID AMIDES PROVOKING A COOLING SENSATION Givaudan SA (CH) 2007-11-14 EP claimed
WO-2007089652-A2 FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE CADBURY ADAMS USA LLC (US) 2007-08-09 WO claimed
US-20070178123-A1 FLAVOR-ENHANCING COMPOSITIONS, METHOD OF MANUFACTURE, AND METHODS OF USE KRAFT FOODS GLOBAL BRANDS LLC 2007-08-02 US claimed
WO-2006092076-A2 CARBOXYLIC ACID AMIDES PROVOKING A COOLING SENSATION GIVAUDAN SA (CH) 2006-09-08 WO claimed
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO claimed
EP-0625996-B1 POLYETHYLENE GLYCOL OR POLYPROPYLENE GLYCOL CONTAINING POLYMER CARLSBERG AS (DK) 1997-04-23 EP claimed
EP-0625996-A1 POLYETHYLENE OR POLYPROPYLENE GLYCOL CONTAINING POLYMER. CARLSBERG AS (DK) 1994-11-30 EP claimed
US-5352756-A Solid support for synthesis of peptides CARLSBERG A/S (DK) 1994-10-04 US claimed
WO-1993016118-A1 POLYETHYLENE OR POLYPROPYLENE GLYCOL CONTAINING POLYMER CARLSBERG A/S (DK) 1993-08-19 WO claimed
CN-120629407-A Method for detecting related substances in imacid dihydrochloride by HPLC (high Performance liquid chromatography) 远大武药(江苏)制药有限公司 2025-09-12 CN disclosed
US-4324889-A 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6β-5-iodo-PGF1 amides THE UPJOHN COMPANY (US) 1982-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711033-B2 Branched chain-containing aromatic compound VIP, IAPP, BCAT1 PRSS1 1983/4885PRSS2 1405/4885PRSS3 1292/4885
US-20080176945-A1 Carboxilic Acid Amides Provoking A Cooling Sensation TRPA1, TRPV1, ASIC1 PRSS1 2959/4885PRSS2 1676/4885PRSS3 2777/4885
US-20110065691-A1 THERAPEUTIC PIPERAZINES PDE4A, PDE4B, PDE4D PRSS1 1409/4885PRSS2 2626/4885PRSS3 1953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.