Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229460 | 0.83 | PGR (0.54) | MCOLN3ALDH1A1SMN1; SMN2HTTHSD11B1 | |
| SCHEMBL17442030 | 0.81 | CYP1A2 (0.48) | MCOLN3ALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL7847967 | 0.79 | MCOLN3 (0.56) | MCOLN3ALDH1A1TSHRHSD11B1LMNA | |
| SCHEMBL12010352 | 0.79 | MCOLN3 (0.56) | MCOLN3ALDH1A1TSHRHSD11B1LMNA | |
| SCHEMBL17760483 | 0.78 | MCOLN3 (0.55) | MCOLN3ALDH1A1TSHRHSD11B1LMNA | |
| SCHEMBL10727766 | 0.78 | ALDH1A1 (0.45) | MCOLN3ALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4033271 | 0.78 | MCOLN3 (0.55) | MCOLN3ALDH1A1TSHRHSD11B1KMT2A | |
| SCHEMBL2633428 | 0.77 | MCOLN3 (0.53) | MCOLN3TSHRHSD11B1LMNAKMT2A | |
| SCHEMBL10455037 | 0.77 | MCOLN3 (0.54) | MCOLN3ALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4027618 | 0.77 | MCOLN3 (0.54) | MCOLN3ALDH1A1TSHRHSD11B1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687502-B2 | Substituted quinazoline or pyridopyrimidine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | MSD K.K. (JP) | 2008-02-07 | — | — | US | disclosed |
| EP-1734040-A1 | SUBSTITUTED QUINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | GCK, GCKR, PDXK | MCOLN3 4156/4885ALDH1A1 1558/4885TSHR 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.