Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | RORA | P35398 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | RORB | Q92753 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13921919 | 0.78 | RORA (0.57) | KDM4EALDH1A1PGRRORARORC | |
| SCHEMBL13640280 | 0.77 | ALDH1A1 (0.54) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6325712 | 0.74 | TP53 (0.59) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31021975 | 0.74 | TP53 (0.59) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11607006 | 0.73 | MEN1 (0.50) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12745350 | 0.70 | NR1I2 (0.38) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3483496 | 0.69 | MEN1 (0.45) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2627061 | 0.68 | PRKCI (0.55) | ALDH1A1KCNH2HTR1DPKMHPGD | |
| SCHEMBL13637248 | 0.68 | KCNH2 (0.50) | KDM4EMEN1KMT2ARORCKCNH2 | |
| SCHEMBL20853226 | 0.68 | ALDH1A1 (0.68) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639347-B2 | Modulators of ATP-binding cassette transporters | CFTR, ABCB1, ABCC2 | KDM4E 4235/4885ALDH1A1 1961/4885MEN1 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.