Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 8/20 | 0.60 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 5/20 | 0.56 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300897 | 0.88 | CCR2 (0.60) | CCR9NOD2NOD1KDM4EMAPT | |
| SCHEMBL5093926 | 0.87 | CCR9 (0.64) | CCR9NOD2NOD1KDM4EMAPT | |
| SCHEMBL1503984 | 0.86 | NOD2 (0.67) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL3209376 | 0.85 | CNR1 (0.49) | CCR9NOD2NOD1KDM4EMAPT | |
| SCHEMBL8692295 | 0.84 | NOD2 (0.58) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL3565301 | 0.83 | NOD2 (0.55) | CCR9NOD2NOD1KDM4EMAPT | |
| SCHEMBL3201430 | 0.83 | NOD2 (0.63) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL8689838 | 0.82 | ALDH1A1 (0.54) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL6307749 | 0.81 | CCR2 (0.74) | NOD2NOD1KDM4EMAPTMAPK1 | |
| SCHEMBL2643108 | 0.81 | CCR9 (0.65) | CCR9CCR2GCGRPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598398-B2 | Acyl indoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | GPR119, IAPP, GLP1R | CCR9 3440/4885NOD2 868/4885NOD1 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.