Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELAVL3 | Q14576 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 2/20 | 0.39 |
| ▸ | TPMT | P51580 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | MMP2 | P08253 | 7/20 | 0.39 |
| ▸ | MMP14 | P50281 | 6/20 | 0.39 |
| ▸ | MMP7 | P09237 | 5/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | PGD | P52209 | 2/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657238 | 0.83 | DYRK1A (0.39) | ELAVL3PGAM1DYRK1AMMP2MMP14 | |
| SCHEMBL2644805 | 0.81 | XDH (0.34) | TPMTKMT2ATDP1PTGS2ALDH1A1 | |
| SCHEMBL2644459 | 0.78 | MEN1 (0.43) | MEN1KMT2AHPGD | |
| SCHEMBL11506396 | 0.77 | TDP1 (0.53) | ELAVL3PGAM1DYRK1AMMP2MMP14 | |
| SCHEMBL644201 | 0.75 | NPC1 (0.43) | KCNH2 | |
| SCHEMBL2643841 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDKCNH2TTR | |
| SCHEMBL2644125 | 0.74 | PTGS2 (0.38) | PTGS2KCNH2TTR | |
| SCHEMBL642185 | 0.73 | HPGD (0.50) | ELAVL3PGAM1DYRK1AMMP2MMP14 | |
| SCHEMBL2644248 | 0.72 | HPGD (0.40) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL22978667 | 0.72 | TDP1 (0.45) | TPMTKDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-B1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | PFIZER PROD INC (US) | 2014-06-11 | — | — | EP | disclosed |
| EP-2010520-B1 | HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PROD INC (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| US-7842713-B2 | Fused phenyl amido heterocyclic compounds | PFIZER INC (US) | 2010-11-30 | — | — | US | disclosed |
| EP-2010520-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | Pfizer Products Incorporated (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2008-11-13 | — | — | US | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280875-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS | GCK, GCKR, HK1 | ELAVL3 4001/4885PGAM1 319/4885TPMT 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.