Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.61 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.57 |
| ▸ | KLK1 | P06870 | 1/20 | 0.57 |
| ▸ | MLYCD | O95822 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6442966 | 0.98 | ALDH1A1 (0.61) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL16168336 | 0.87 | HDAC6 (0.59) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL29043470 | 0.84 | HDAC3 (0.56) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL28748909 | 0.84 | CA2 (0.60) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL8590217 | 0.84 | MLYCD (0.70) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL3363186 | 0.83 | ALDH1A1 (0.65) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL14380335 | 0.83 | TAS1R3 (0.67) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL506657 | 0.83 | HDAC3 (0.54) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL25711087 | 0.83 | HDAC3 (0.54) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL6342962 | 0.82 | ALDH1A1 (0.69) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606520-B2 | Calpain-2 inhibitor compounds and methods of treatment | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2026-04-21 | — | — | US | disclosed |
| US-20240026358-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2024-01-25 | — | — | US | disclosed |
| WO-2023148643-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-10 | — | — | WO | disclosed |
| US-20230091121-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | UNITED STATES GOVERNMENT | 2023-03-23 | — | — | US | disclosed |
| WO-2021163631-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021163631-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2021-08-19 | — | — | WO | disclosed |
| WO-2018048752-A1 | LIPSOMAL ANTICANCER COMPOSITIONS | IRISYS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| US-8765789-B2 | 2-pyridinecarboxamide derivatives | MSD K.K. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2013-04-04 | — | — | US | disclosed |
| US-8344003-B2 | 2-pyridinecarboxamide derivatives | MSD K. K. (JP) | 2013-01-01 | — | — | US | disclosed |
| WO-2010120592-A1 | COMBINATION THERAPY USING AN ANTI-EGFR AGENT(S) AND IGF-1R SPECIFIC INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | WO | disclosed |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2010-02-18 | — | — | US | disclosed |
| US-7629362-B2 | 2-pyridine carboxamide derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-12-08 | — | — | US | disclosed |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-16 | — | — | US | disclosed |
| EP-1598349-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091121-A1 | CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT | CAPN2, CAPNS1, CAPN1 | ALDH1A1 3467/4885LMNA 940/4885CYP1A2 3822/4885 |
| US-12606520-B2 | Calpain-2 inhibitor compounds and methods of treatment | CAPN2, CAPN1, CAPNS1 | ALDH1A1 3630/4885LMNA 1021/4885CYP1A2 3243/4885 |
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | ALDH1A1 1207/4885LMNA 4727/4885CYP1A2 1518/4885 |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | GCKR, GCK, HK2 | ALDH1A1 1249/4885LMNA 4724/4885CYP1A2 1602/4885 |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | ALDH1A1 1207/4885LMNA 4727/4885CYP1A2 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.