Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | ATIC | P31939 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025002 | 0.87 | CYP1A2 (0.64) | CYP1A2ATICMEN1KMT2ATHRB | |
| SCHEMBL14025046 | 0.82 | ATIC (0.58) | PHLPP2CYP1A2ATICMEN1KMT2A | |
| SCHEMBL29377176 | 0.78 | CYP1A2 (0.69) | CYP1A2ATICMEN1KMT2ATHRB | |
| SCHEMBL14418550 | 0.78 | CYP1A2 (0.67) | PHLPP2CYP1A2MEN1KMT2ATHRB | |
| SCHEMBL19234932 | 0.78 | CD40 (0.59) | PHLPP2MEN1KMT2ATHRBTDP1 | |
| SCHEMBL18828469 | 0.78 | CYP1A2 (0.53) | PHLPP2CYP1A2ATICMEN1KMT2A | |
| SCHEMBL8844263 | 0.78 | PHLPP2 (0.67) | PHLPP2CYP1A2ATICMEN1KMT2A | |
| SCHEMBL8844274 | 0.78 | PHLPP2 (0.67) | PHLPP2CYP1A2ATICMEN1KMT2A | |
| SCHEMBL8844279 | 0.78 | PHLPP2 (0.67) | PHLPP2CYP1A2ATICMEN1KMT2A | |
| SCHEMBL2987080 | 0.77 | CYP1A2 (0.71) | PHLPP2CYP1A2ATICMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, HMOX1, NFE2L2 | PHLPP2 1536/4885CYP1A2 3090/4885ATIC 2705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.