Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465562 | 0.89 | SMN1; SMN2 (0.57) | CACNA1HSMN1; SMN2ALDH1A1CXCR6DRD4 | |
| SCHEMBL26466598 | 0.87 | CACNA1H (0.46) | CACNA1HSMN1; SMN2KCNJ5KCNJ3EPHX2 | |
| SCHEMBL26466207 | 0.87 | CACNA1H (0.46) | CACNA1HSMN1; SMN2KCNJ5KCNJ3EPHX2 | |
| SCHEMBL26464504 | 0.87 | CACNA1H (0.52) | CACNA1HSMN1; SMN2ALDH1A1DRD4MAPT | |
| SCHEMBL26465696 | 0.85 | CACNA1H (0.44) | CACNA1HALDH1A1HPGDDRD4KDM4E | |
| SCHEMBL26464500 | 0.83 | CACNA1H (0.70) | CACNA1HCXCR6DRD4MAPT | |
| SCHEMBL26465812 | 0.81 | CACNA1H (0.47) | CACNA1HALDH1A1HPGDTSHRKDM4E | |
| SCHEMBL26465553 | 0.80 | CACNA1H (0.49) | CACNA1HSMN1; SMN2ALDH1A1CXCR6KDM4E | |
| SCHEMBL26465573 | 0.79 | CACNA1H (0.72) | CACNA1HSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL26465838 | 0.77 | CACNA1H (0.55) | CACNA1HALDH1A1CXCR6DRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |