Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31477886 | 1.00 | TAAR1 (0.52) | TAAR1DAOKMT2AMAOBHRH1 | |
| Hydrochloric Acid SCHEMBL2130617 | 0.98 | TAAR1 (0.50) | TAAR1DAOKMT2AMAOBHRH1 | |
| SCHEMBL2550872 | 0.84 | KMT2A (0.52) | TAAR1DAOKMT2AMAOBKDM1A | |
| SCHEMBL29408885 | 0.84 | KMT2A (0.52) | TAAR1DAOKMT2AMAOBKDM1A | |
| Hydrochloric Acid SCHEMBL23572864 | 0.82 | KMT2A (0.50) | TAAR1DAOKMT2AMAOBKDM1A | |
| Hydrochloric Acid SCHEMBL3902582 | 0.82 | KMT2A (0.50) | TAAR1DAOKMT2AMAOBKDM1A | |
| SCHEMBL10115954 | 0.81 | DAO (0.50) | DAOKMT2AMAOBKDM1AMAOA | |
| SCHEMBL29852337 | 0.81 | DAO (0.50) | DAOKMT2AMAOBKDM1AMAOA | |
| SCHEMBL27713067 | 0.81 | DAO (0.50) | DAOKMT2AMAOBKDM1AMAOA | |
| SCHEMBL1311062 | 0.81 | DAO (0.50) | DAOKMT2AMAOBKDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558944-B1 | HYDROGENATION OF A SUBSTITUTED 2-METHYL CYANOPYRIDYL DERIVATIVE IN THE PRESENCE OF A RANEY COBALT CATALYST | BAYER CROPSCIENCE AG (DE) | 2022-03-09 | — | — | EP | disclosed |
| US-10766859-B2 | Catalytic hydrogenation of nitriles | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-09-08 | — | — | US | disclosed |
| US-20200039936-A1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2020-02-06 | — | — | US | disclosed |
| EP-3558944-A1 | CATALYTIC HYDROGENATION OF NITRILES | Bayer CropScience Aktiengesellschaft (DE) | 2019-10-30 | — | — | EP | disclosed |
| US-10414730-B2 | Catalytic hydrogenation of nitriles | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-09-17 | — | — | US | disclosed |
| US-20180244621-A1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-08-30 | — | — | US | disclosed |
| WO-2018114810-A1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-06-28 | — | — | WO | disclosed |
| US-9988353-B2 | Catalytic hydrogenation of nitriles | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-06-05 | — | — | US | disclosed |
| EP-3068766-B1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AG (DE) | 2018-01-10 | — | — | EP | disclosed |
| US-20160280648-A1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-09-29 | — | — | US | disclosed |
| EP-3068766-A1 | CATALYTIC HYDROGENATION OF NITRILES | Bayer CropScience Aktiengesellschaft (DE) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015071230-A1 | CATALYTIC HYDROGENATION OF NITRILES | BAYER CROPSCIENCE AG (DE) | 2015-05-21 | — | — | WO | disclosed |
| US-8133909-B2 | Heteroaromatic monoamides as orexinin receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| CN-102066325-A | Heteroaromatic monoamides as orexin receptor antagonists | HOFFMANN LA ROCHE | 2011-05-18 | — | — | CN | disclosed |
| EP-2297102-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009153180-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-23 | — | — | WO | disclosed |
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10766859-B2 | Catalytic hydrogenation of nitriles | HNMT, NUP50, HCN2 | TAAR1 2302/4885DAO 642/4885KMT2A 1306/4885 |
| US-20090312314-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPSR1 | TAAR1 68/4885DAO 1311/4885KMT2A 762/4885 |
| US-20180244621-A1 | CATALYTIC HYDROGENATION OF NITRILES | PNMT, HNMT, HPD | TAAR1 1438/4885DAO 260/4885KMT2A 477/4885 |
| US-20200039936-A1 | CATALYTIC HYDROGENATION OF NITRILES | HNMT, NUP50, HCN2 | TAAR1 2302/4885DAO 642/4885KMT2A 1306/4885 |
| US-20160280648-A1 | CATALYTIC HYDROGENATION OF NITRILES | PNMT, HNMT, PYCR1 | TAAR1 1360/4885DAO 322/4885KMT2A 479/4885 |
| US-10414730-B2 | Catalytic hydrogenation of nitriles | PNMT, HNMT, HPD | TAAR1 1438/4885DAO 260/4885KMT2A 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.