Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466230 | 0.88 | HTT (0.55) | CACNA1HTHRBHPGDTSHRHTT | |
| SCHEMBL26466418 | 0.88 | HTT (0.55) | CACNA1HTHRBHPGDTSHRHTT | |
| SCHEMBL26466245 | 0.88 | HTT (0.55) | CACNA1HTHRBHPGDTSHRHTT | |
| SCHEMBL26466777 | 0.86 | ALDH1A1 (0.45) | CACNA1HLTA4HL3MBTL1TSHRHTT | |
| SCHEMBL26467008 | 0.85 | ALDH1A1 (0.53) | CACNA1HL3MBTL1HPGDTSHRHTT | |
| SCHEMBL26466596 | 0.84 | CACNA1H (0.40) | SIGMAR1TMEM97DRD4CACNA1HLTA4H | |
| SCHEMBL26466916 | 0.83 | SIGMAR1 (0.42) | SIGMAR1TMEM97DRD4CACNA1HDRD3 | |
| SCHEMBL26466611 | 0.82 | HTT (0.55) | CACNA1HTHRBHPGDTSHRHTT | |
| SCHEMBL26466402 | 0.81 | CACNA1H (0.65) | CACNA1H | |
| SCHEMBL26466613 | 0.81 | CACNA1H (0.52) | CACNA1HLTA4HL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |