Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750855 | 0.90 | IMPDH2 (0.53) | ALDH1A1KDM4EHSD17B10IMPDH2IMPDH1 | |
| SCHEMBL70429 | 0.84 | LMNA (0.59) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL181067 | 0.82 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL2383149 | 0.81 | CA12 (0.48) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL30506574 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL646271 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL14050225 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL13209911 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EIMPDH2IMPDH1TSHR | |
| SCHEMBL11281530 | 0.80 | IMPDH2 (0.54) | ALDH1A1KDM4EHSD17B10IMPDH2IMPDH1 | |
| SCHEMBL1708879 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KDM4EHSD17B10TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-1140823-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039088-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-06 | — | — | WO | disclosed |