SCHEMBL2647429

SCHEMBL2647429

Nc1cc(-n2cccc2)ccc1Nc1cccc(-c2ccccn2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.42
CNR1 P21554 1/20 0.40
HTR1A P08908 1/20 0.38
HTR7 P34969 1/20 0.38
GRM5 P41594 1/20 0.37
DHFR P00374 1/20 0.36
PTGS2 P35354 1/20 0.36
FGFR3 P22607 1/20 0.36
KDR P35968 1/20 0.36
CSNK2A2 P19784 1/20 0.36
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
MAPK14 Q16539 1/20 0.35
SCN9A Q15858 1/20 0.35
SYK P43405 1/20 0.35
BACE1 P56817 1/20 0.34
CDK1 P06493 2/20 0.34
CSNK1A1 P48729 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2645891 0.81 MEN1 (0.43) RETCNR1KMT2ATDP1
SCHEMBL2645152 0.81 RET (0.45) RETCNR1HTR1AHTR7CSNK2A2
SCHEMBL2647045 0.80 MEN1 (0.43) CNR1DHFRKDRHDAC1HDAC2
SCHEMBL2647222 0.79 CNR1 (0.38) CNR1DHFRFGFR3KDRHDAC1
SCHEMBL8323635 0.76 DHFR (0.40) DHFRNPC1SYKCDK1CDK2
SCHEMBL2648414 0.76 CNR1 (0.49) RETCNR1KDRHDAC2NPC1
SCHEMBL30103987 0.75 CNR1 (0.56) RETCNR1HTR1AHTR7CSNK2A2
SCHEMBL15606453 0.75 CNR1 (0.56) RETCNR1HTR1AHTR7CSNK2A2
SCHEMBL6797326 0.72 CNR1 (0.46) RETCNR1NPC1SYKCDK1
SCHEMBL10064753 0.72 CNR1 (0.54) RETCNR1HTR1AHTR7KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821683-B1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A RECEPTOR COMPLEX NEUROSEARCH AS (DK) 2006-11-02 EP disclosed
US-5902813-A MODULATORS OF THE BENZODIAXEPINE RECEPTOR OT THE GAMMA-BUTYRIC ACID(A) RECEPTOR COMPLEX; ANXIOLYTIC, ANTIEPILEPTIC AND -CONVULSANT AGENTS; SLEEP AND MEMORY DISORDERS NEUROSEARCH A/S (DK) 1999-05-11 US disclosed
EP-0821683-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1998-02-04 EP disclosed
WO-1996033192-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1996-10-24 WO disclosed