Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2647222 | 0.83 | CNR1 (0.38) | DHFREGFRGAAMAPTKDM4E | |
| SCHEMBL5755261 | 0.83 | L3MBTL1 (0.39) | MAPTL3MBTL1 | |
| SCHEMBL7834583 | 0.80 | ALDH1A1 (0.37) | DHFRMAP4K4 | |
| SCHEMBL2647045 | 0.80 | MEN1 (0.43) | DHFREGFRABL1PDGFRBBCR | |
| SCHEMBL2643726 | 0.77 | ALK (0.42) | DHFREGFR | |
| SCHEMBL2647429 | 0.76 | RET (0.42) | DHFRGAANPSR1NPC1CDK1 | |
| SCHEMBL2655356 | 0.70 | ABL1 (0.47) | MAPTSYKABL1PDGFRBBCR | |
| SCHEMBL2643742 | 0.69 | MAP4K4 (0.42) | MAP4K4GAAMAPTKDM4EL3MBTL1 | |
| SCHEMBL2643607 | 0.69 | HDAC2 (0.39) | GAAMAPTKDM4EL3MBTL1NPC1 | |
| SCHEMBL2643560 | 0.67 | MAP4K4 (0.65) | DHFRMAP4K4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902813-A | MODULATORS OF THE BENZODIAXEPINE RECEPTOR OT THE GAMMA-BUTYRIC ACID(A) RECEPTOR COMPLEX; ANXIOLYTIC, ANTIEPILEPTIC AND -CONVULSANT AGENTS; SLEEP AND MEMORY DISORDERS | NEUROSEARCH A/S (DK) | 1999-05-11 | — | — | US | disclosed |