Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 3/20 | 0.42 |
| ▸ | PLOD3 | O60568 | 3/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1439664 | 0.85 | MAPT (0.51) | ALDH1A1MAPTGAA | |
| SCHEMBL3284705 | 0.81 | KDM4E (0.52) | ALDH1A1LMNAMAPTGRM5MEN1 | |
| SCHEMBL3073424 | 0.81 | NT5E (0.55) | ALDH1A1LMNAHPGDMAPTGAA | |
| SCHEMBL1156959 | 0.81 | CES2 (0.50) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1845879 | 0.81 | MAPT (0.49) | ALDH1A1LMNAPLOD2PLOD3PLOD1 | |
| SCHEMBL6282499 | 0.79 | GRM1 (0.46) | ALDH1A1LMNAPLOD2PLOD3PLOD1 | |
| SCHEMBL1157353 | 0.79 | ALDH1A1 (0.66) | ALDH1A1LMNAPLOD2PLOD3PLOD1 | |
| SCHEMBL2477853 | 0.77 | LMNA (0.54) | ALDH1A1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1847397 | 0.77 | GSK3B (0.59) | LMNAVNN1GRM5 | |
| SCHEMBL2929610 | 0.77 | VNN1 (0.57) | ALDH1A1VNN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |