Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955381 | 0.83 | CYP1A1 (0.45) | KMT2AKDM4ECYP1A1CYP1B1ALDH1A1 | |
| SCHEMBL22160268 | 0.82 | MAPT (0.46) | THRALMNAPOLBRAB9AL3MBTL1 | |
| SCHEMBL22160250 | 0.80 | L3MBTL1 (0.45) | KDM4ELMNAALDH1A1POLBRAB9A | |
| SCHEMBL28519834 | 0.79 | TDP1 (0.51) | THRATHRBKMT2AKDM4ECYP1A2 | |
| SCHEMBL8218438 | 0.79 | LMNA (0.55) | KMT2AKDM4ECYP1A2LMNAMAOB | |
| SCHEMBL28529318 | 0.79 | KMT2A (0.57) | KMT2AKDM4ELMNAMEN1ALDH1A1 | |
| SCHEMBL12418029 | 0.78 | LMNA (0.55) | THRBKMT2AKDM4ECYP1A2LMNA | |
| SCHEMBL955308 | 0.78 | PTGDR2 (0.48) | THRATHRBKMT2AKDM4EALDH1A1 | |
| SCHEMBL6835721 | 0.77 | KMT2A (0.53) | KMT2AKDM4ECYP1A2CYP2D6SCN1A | |
| SCHEMBL4841763 | 0.77 | NPC1 (0.57) | KMT2ACYP1A2LMNAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959886-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0959886-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5880139-A | TREATING DIABETES, OBESITY, HYPERTENSION, CACHEXIA | MERCK & CO., INC. (US) | 1999-03-09 | — | — | US | disclosed |
| WO-1998022109-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AS GLUCAGON ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |