Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833864 | 0.87 | MAPT (0.58) | KMT2AMEN1LMNATSHRABCG2 | |
| SCHEMBL15782821 | 0.86 | KMT2A (0.44) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL4097250 | 0.86 | MAPT (0.50) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL11653015 | 0.86 | NPC1 (0.60) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL8817111 | 0.86 | NPC1 (0.53) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL5767131 | 0.85 | KMT2A (0.43) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL1436315 | 0.85 | NPC1 (0.58) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL12857970 | 0.83 | HTT (0.53) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL25343037 | 0.82 | CTSL (0.45) | NPC1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL6496479 | 0.82 | ALDH1A1 (0.63) | KMT2AMEN1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | EMORY UNIVERSITY (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | UNIV EMORY (US) | 2020-08-27 | — | — | US | disclosed |
| WO-2019023448-A1 | NADPH OXIDASE INHIBITORS AND USES THEREOF | EMORY UNIVERSITY (US) | 2019-01-31 | — | — | WO | disclosed |
| US-7423030-B2 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-09-09 | — | — | US | disclosed |
| EP-1737840-B1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-09-12 | — | — | EP | disclosed |
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-05-03 | — | — | US | disclosed |
| EP-1737840-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005103033-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-11-03 | — | — | WO | disclosed |
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270214-A1 | NADPH Oxidase Inhibitors and Uses Thereof | NOX1, NOX3, NOX5 | NPC1 2534/4885KMT2A 2871/4885MEN1 4554/4885 |
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | CYP11B2, CYP11B1, GOT2 | NPC1 204/4885KMT2A 1683/4885MEN1 866/4885 |
| US-11236053-B2 | NADPH oxidase inhibitors and uses thereof | NOX1, NOX3, NOX5 | NPC1 2534/4885KMT2A 2871/4885MEN1 4554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.