Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26493523 | 0.78 | EGFR (0.42) | — | |
| SCHEMBL1519758 | 0.71 | CYP3A4 (0.49) | CYP3A4 | |
| SCHEMBL1519743 | 0.71 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL29935862 | 0.71 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL22288360 | 0.70 | BACE1 (0.49) | CCNE1CDK2CDK5ROCK1PRKCZ | |
| SCHEMBL27721788 | 0.70 | CYP3A4 (0.51) | CYP3A4 | |
| SCHEMBL22288202 | 0.69 | CYP11B2 (0.51) | CCNE1CDK2CDK5ROCK1PRKCZ | |
| SCHEMBL2300247 | 0.66 | PRKCZ (0.45) | CCNE1CDK2CDK5ROCK1PRKCZ | |
| SCHEMBL23987063 | 0.66 | CLK1 (0.49) | CCNE1CDK2CDK5 | |
| SCHEMBL26463977 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072969-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |