Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 6/20 | 0.36 |
| ▸ | THRB | P10828 | 6/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649949 | 0.85 | ALDH1A1 (0.64) | ALDH1A1MAPK1KMT2AMEN1HPGD | |
| SCHEMBL31084168 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MAPK1KLK1THRATHRB | |
| SCHEMBL2651217 | 0.79 | SRC (0.47) | ALDH1A1MAPK1THRATHRBALDH1A3 | |
| SCHEMBL3903040 | 0.79 | THRA (0.57) | ALDH1A1MAPK1KLK1THRATHRB | |
| SCHEMBL9858621 | 0.77 | KLK1 (0.41) | ALDH1A1KLK1THRATHRBKMT2A | |
| SCHEMBL2650280 | 0.77 | FDPS (0.51) | ALDH1A1MAPK1KMT2AMEN1HPGD | |
| SCHEMBL14862481 | 0.76 | HPGD (0.39) | ALDH1A1MAPK1KMT2AMEN1HPGD | |
| SCHEMBL7168103 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPK1THRATHRBKMT2A | |
| SCHEMBL25923588 | 0.76 | MAPT (0.37) | ALDH1A1HPGDSMN1; SMN2LMNAMAPT | |
| SCHEMBL13554474 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPK1THRBALDH1A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0994848-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |