Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652551 | 0.84 | FFAR1 (0.41) | ALDH1A1KDM4ETSHRFFAR1ALKBH1 | |
| SCHEMBL2652111 | 0.81 | IDO1 (0.41) | ALDH1A1KDM4ETSHRFFAR1SGMS2 | |
| SCHEMBL2652010 | 0.80 | IDO1 (0.40) | GAAKMT2AMAOB | |
| SCHEMBL2651003 | 0.80 | IDO1 (0.40) | HTTALDH1A1FFAR1KMT2ATDP1 | |
| SCHEMBL2652007 | 0.80 | TSHR (0.43) | ALDH1A1KDM4ETSHRMAOB | |
| SCHEMBL2651154 | 0.79 | MRGPRX4 (0.52) | TP53MRGPRX4KMT2A | |
| SCHEMBL2651078 | 0.76 | IDO1 (0.44) | HTTALDH1A1GAAMAOB | |
| SCHEMBL2650744 | 0.73 | MAPK14 (0.37) | ALDH1A1TSHRFFAR1SGMS2 | |
| SCHEMBL2650713 | 0.72 | MAPK14 (0.37) | ALDH1A1TSHRFFAR1SGMS2 | |
| SCHEMBL2650379 | 0.71 | KAT6A (0.33) | ALDH1A1KMT2ASGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |