Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652551 | 0.88 | FFAR1 (0.41) | ALDH1A1TDP1L3MBTL1SMN1; SMN2MAOB | |
| SCHEMBL2650744 | 0.87 | MAPK14 (0.37) | ALDH1A1KCNH2MAPK14HTR2APOLB | |
| SCHEMBL2650379 | 0.86 | KAT6A (0.33) | IDO1ALDH1A1L3MBTL1HTR2ASMN1; SMN2 | |
| SCHEMBL2652111 | 0.84 | IDO1 (0.41) | IDO1ALDH1A1SMN1; SMN2MAOBPARP10 | |
| SCHEMBL2652478 | 0.83 | IDO1 (0.48) | IDO1ALDH1A1MCL1SMN1; SMN2MAOB | |
| SCHEMBL2652010 | 0.83 | IDO1 (0.40) | IDO1L3MBTL1MAOBKMT2ANPC1 | |
| SCHEMBL2652007 | 0.83 | TSHR (0.43) | ALDH1A1L3MBTL1MAOBLMNA | |
| SCHEMBL2651078 | 0.82 | IDO1 (0.44) | IDO1ALDH1A1SMN1; SMN2MAOBHTT | |
| SCHEMBL2650713 | 0.80 | MAPK14 (0.37) | ALDH1A1KCNH2MAPK14HTR2APOLB | |
| SCHEMBL2650110 | 0.80 | TP53 (0.41) | ALDH1A1TDP1MAOBKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |