Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3271842 | 0.89 | MAOB (0.52) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3269606 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3269301 | 0.83 | MAPT (0.59) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2648036 | 0.82 | MAPT (0.48) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3267168 | 0.80 | MRGPRX4 (0.43) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3267969 | 0.80 | ALDH1A1 (0.47) | KMT2AMAOBALDH1A1HPGDGSK3B | |
| SCHEMBL3268166 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2664414 | 0.78 | KMT2A (0.49) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3272664 | 0.78 | ENPP2 (0.52) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2663789 | 0.78 | PTPN1 (0.45) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1267281-A | Glucagon antagonists/inverse agonists | NOVO NORDISK AS (DK) | 2000-09-20 | — | — | CN | disclosed |
| EP-0994848-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |