Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649094 | 0.85 | BACE1 (0.37) | SNCAMAPK14PTGS1 | |
| SCHEMBL1136930 | 0.81 | LPL (0.52) | LPLLIPGSNCAPTGS2PTGS1 | |
| SCHEMBL20904948 | 0.81 | LIPG (0.68) | LPLLIPGPDGFRBKDR | |
| SCHEMBL2658079 | 0.80 | ERN1 (0.42) | SNCA | |
| SCHEMBL2649122 | 0.79 | GABRA1 (0.39) | SNCA | |
| SCHEMBL2649221 | 0.79 | GABRA1 (0.35) | SNCA | |
| SCHEMBL2649142 | 0.77 | PGR (0.38) | — | |
| SCHEMBL6219095 | 0.77 | SNCA (0.34) | SNCA | |
| SCHEMBL5892525 | 0.76 | EGFR (0.39) | SNCA | |
| SCHEMBL2659509 | 0.75 | GABRA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006464-A1 | (1,8) NAPHTHYRIDINES AS GABA LIGANDS, THEIR PHARMACEUTICAL COMPOSITIONS AND USES | MERCK SHARP & DOHME LIMITED (GB) | 2003-01-23 | — | — | WO | disclosed |