Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650061 | 0.85 | IDO1 (0.42) | IDO1MAOB | |
| SCHEMBL2652312 | 0.83 | GLA (0.45) | MAOB | |
| SCHEMBL2651330 | 0.82 | CYP3A4 (0.42) | IDO1AGXTMAOBRAB9ANPC1 | |
| SCHEMBL2651154 | 0.79 | MRGPRX4 (0.52) | RAB9ANPC1 | |
| SCHEMBL2651208 | 0.76 | IDO1 (0.54) | IDO1AGXTABCB1HTR1ADRD2 | |
| SCHEMBL2652551 | 0.74 | FFAR1 (0.41) | MAOBRAB9ANPC1 | |
| SCHEMBL11118935 | 0.73 | ABCB1 (0.58) | ABCB1HTR1ADRD2TAAR1 | |
| SCHEMBL2652007 | 0.72 | TSHR (0.43) | MAOB | |
| SCHEMBL2650379 | 0.72 | KAT6A (0.33) | IDO1 | |
| SCHEMBL17217219 | 0.72 | IDO1 (0.47) | IDO1AGXTABCB1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |