Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | AGXT | P21549 | 2/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12220716 | 0.78 | IDO1 (0.62) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL6202881 | 0.78 | AOC3 (0.50) | CASRL3MBTL1 | |
| SCHEMBL2093766 | 0.77 | L3MBTL1 (0.53) | TAAR1CASRL3MBTL1 | |
| SCHEMBL12093568 | 0.77 | IDO1 (0.61) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL14731903 | 0.76 | TAAR1 (0.67) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL2651467 | 0.76 | IDO1 (0.44) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL2650837 | 0.74 | IDO1 (0.51) | IDO1AGXTMAOBFFAR1 | |
| SCHEMBL3768643 | 0.74 | IDO1 (0.71) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL31264 | 0.74 | IDO1 (0.71) | IDO1AGXTTAAR1MAOBABCB1 | |
| SCHEMBL8009506 | 0.74 | MTNR1A (0.55) | CASRMAOBFFAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |