Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | CCR7 | P32248 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | GLS | O94925 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650998 | 0.81 | CFD (0.39) | FFAR4IDO1AKR1B1 | |
| SCHEMBL2652478 | 0.79 | IDO1 (0.48) | IDO1ALDH1A1MAOBTDO2 | |
| SCHEMBL5140181 | 0.72 | IDO1 (0.45) | CES2CES1FFAR4IDO1ALKBH1 | |
| SCHEMBL2651003 | 0.71 | IDO1 (0.40) | IDO1ALDH1A1MAOB | |
| SCHEMBL2642685 | 0.69 | IDO1 (0.42) | FFAR4IDO1ALKBH1RIPK1ALDH1A1 | |
| SCHEMBL5543468 | 0.68 | IDO1 (0.38) | CES2CES1FFAR4IDO1ALKBH1 | |
| SCHEMBL323427 | 0.68 | FFAR4 (0.43) | CES2CES1FFAR4IDO1ALKBH1 | |
| SCHEMBL7193516 | 0.68 | IDO1 (0.38) | CES2CES1FFAR4IDO1ALKBH1 | |
| SCHEMBL4799320 | 0.67 | RIPK1 (0.34) | FFAR4ALKBH1RIPK1OGACXCR2 | |
| SCHEMBL2650913 | 0.67 | IDO1 (0.50) | FFAR4IDO1ALDH1A1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |