SCHEMBL2651602

SCHEMBL2651602

O=C(Oc1ccc(F)cc1)C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 0.45
KMT2A Q03164 2/20 0.42
ATM Q13315 1/20 0.42
GAA P10253 1/20 0.42
PLOD2 O00469 1/20 0.41
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
KIF11 P52732 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26343991 0.84 ELANE (0.53) ELANEKMT2AGAAKDM4E
SCHEMBL10180496 0.83 ELANE (0.42) ELANEKMT2AATMGAACES2
SCHEMBL24142228 0.82 ELANE (0.41) ELANEKMT2AATMGAACES2
SCHEMBL326469 0.81 ELANE (0.44) ELANEKIF11
SCHEMBL9872338 0.81 LMNA (0.57) ELANEKMT2AGAAALDH1A1CYP1A2
SCHEMBL27746984 0.81 ELANE (0.48) ELANEGAACES2CES1SMN1; SMN2
SCHEMBL10738024 0.81 ELANE (0.56) ELANEKMT2ASMN1; SMN2CYP1A2HPGD
SCHEMBL8538472 0.81 ELANE (0.44) ELANEKMT2ACES2CES1KIF11
SCHEMBL13551942 0.81 ELANE (0.70) ELANEKMT2A
SCHEMBL24361865 0.80 ELANE (0.40) ELANEKMT2AATMGAAKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4668830-A Process for the preparation of compounds containing a difluoromethylene or trifluoromethyl group RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1987-05-26 US claimed
US-20260070864-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING FLUOROALKYL GROUP DAIKIN INDUSTRIES, LTD. (JP) 2026-03-12 US disclosed
EP-4685127-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING FLUOROALKYL GROUP Daikin Industries, Ltd. (JP) 2026-01-28 EP disclosed
WO-2024237156-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING FLUOROALKYL GROUP ダイキン工業株式会社 2024-11-21 WO disclosed
CN-104112870-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2014-10-22 CN disclosed
US-20130244122-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME ONUKI MASAMICHI (JP) 2013-09-19 US disclosed
US-20120219866-A1 NONAQUEOUS ELECTROLYTIC SOLUTION AND NONAQUEOUS-ELECTROLYTE BATTERY EMPLOYING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2012-08-30 US disclosed
EP-2475041-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION, AND NON-AQUEOUS ELECTROLYTE BATTERY COMPRISING SAME Mitsubishi Chemical Corporation (JP) 2012-07-11 EP disclosed
CN-102484281-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2012-05-30 CN disclosed
EP-1648455-A4 ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE EXELIXIS INC (US) 2009-03-04 EP disclosed
EP-1648455-A2 ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE Exelixis, Inc. (US) 2006-04-26 EP disclosed
WO-2005009389-A2 ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE EXELIXIS, INC. (US) 2005-02-03 WO disclosed
WO-2002099141-A9 FLUORESCENT QUENCHING DETECTION REAGENTS AND METHODS EPOCH BIOSCIENCES INC (US) 2004-05-27 WO disclosed
WO-2002070469-A2 SELECTIVE PDE3B INHIBITORS AND USE OF THE SAME IN THERAPY ICOS CORPORATION (US) 2002-09-12 WO disclosed
EP-1183229-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2002-03-06 EP disclosed
EP-1173427-A1 HYDROXAMIC ACID DERIVATIVE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2002-01-23 EP disclosed
WO-2000069810-A1 GLUCAGON ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2000-11-23 WO disclosed
WO-2000063197-A1 HYDROXAMIC ACID DERIVATIVE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2000-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070864-A1 METHOD FOR PRODUCING AROMATIC COMPOUND HAVING FLUOROALKYL GROUP AFF1, NAF1, AFF2 ELANE 3463/4885KMT2A 2373/4885ATM 1010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.