Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 4/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270067 | 0.77 | ALDH1A1 (0.47) | NPC1RAB9AADAMTS4ADAMTS5MAPT | |
| SCHEMBL2651560 | 0.76 | S1PR1 (0.62) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2652250 | 0.74 | NPC1 (0.56) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL5660957 | 0.73 | PPARG (0.81) | PPARGPPARDPPARA | |
| SCHEMBL2654593 | 0.72 | NPC1 (0.59) | S1PR1S1PR3NPC1RAB9AMEN1 | |
| SCHEMBL6031191 | 0.71 | ITGB3 (0.64) | ITGB3ITGA2BRAB9AMEN1KMT2A | |
| SCHEMBL1122857 | 0.71 | GPR132 (0.67) | PPARGITGB3ITGA2BRAB9A | |
| SCHEMBL27659028 | 0.71 | GPR132 (0.67) | PPARGITGB3ITGA2BRAB9A | |
| SCHEMBL27658965 | 0.71 | GAA (0.69) | PPARGITGB3ITGA2BRAB9AMEN1 | |
| SCHEMBL1122645 | 0.71 | GAA (0.69) | PPARGITGB3ITGA2BRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |