Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | SI | P14410 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1607268 | 0.80 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1606455 | 0.77 | NPC1 (0.79) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL23727897 | 0.70 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL30136193 | 0.70 | NPC1 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10686239 | 0.70 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11924959 | 0.67 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7455707 | 0.67 | MAPT (0.45) | RAB9AMAPTMEN1KMT2ALMNA | |
| SCHEMBL3140019 | 0.66 | ADORA2A (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27702357 | 0.63 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14886072 | 0.62 | KCNMA1 (1.00) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549638-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031179-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-15 | — | — | WO | disclosed |