Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | CTSV | O60911 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.45 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | MAX | P61244 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16950726 | 0.85 | AKR1C3 (0.44) | AKR1C3AKR1C2ALDH1A1MAPTCTSV | |
| SCHEMBL2647221 | 0.84 | AKR1C3 (0.47) | AKR1C3AKR1C2ALDH1A1MAPTCTSV | |
| SCHEMBL17182678 | 0.82 | AKR1C3 (0.43) | AKR1C3AKR1C2ALDH1A1MAPTCTSV | |
| SCHEMBL20679607 | 0.81 | AKR1C3 (0.52) | AKR1C3AKR1C2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL20679615 | 0.81 | AKR1C3 (0.52) | AKR1C3AKR1C2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL9367150 | 0.80 | AKR1C3 (0.50) | AKR1C3AKR1C2ALDH1A1MAPTTDP1 | |
| SCHEMBL16961001 | 0.80 | ALDH1A1 (0.43) | AKR1C3AKR1C2ALDH1A1MAPTTDP1 | |
| SCHEMBL1612471 | 0.80 | AKR1C3 (0.44) | AKR1C3AKR1C2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL725163 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTCTSVCTSLCYP3A4 | |
| SCHEMBL8431994 | 0.80 | GPR35 (0.51) | AKR1C3AKR1C2ALDH1A1MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551793-B1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | AMKOR PHARMA INC (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | NOVO NORDISK A/S (DK) | 2009-06-04 | — | — | US | disclosed |
| US-7511074-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080227859-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-7371896-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7319160-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | AMKOR PHARMA, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-20070078183-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2007-04-05 | — | — | US | disclosed |
| EP-1551793-A4 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | NEUROTECH CO LTD (KR) | 2007-04-04 | — | — | EP | disclosed |
| US-7189878-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2007-03-13 | — | — | US | disclosed |
| US-20060235239-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2006-10-19 | — | — | US | disclosed |
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2005-09-15 | — | — | US | disclosed |
| US-6927303-B2 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH CO., LTD. (KR) | 2005-08-09 | — | — | US | disclosed |
| EP-1551793-A1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | Neurotech Co., Ltd. (KR) | 2005-07-13 | — | — | EP | disclosed |
| US-6875760-B2 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2005-04-05 | — | — | US | disclosed |
| US-20040209957-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2004-10-21 | — | — | US | disclosed |
| WO-2004000786-A1 | TETRAFLUOROBENZYL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ACUTE AND CHRONIC NEURODEGENERATIVE DISEASES IN CENTRAL NERVOUS SYSTEM CONTAINING THE SAME | NEUROTECH CO., LTD. (KR) | 2003-12-31 | — | — | WO | disclosed |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-11-27 | — | — | US | disclosed |
| US-6503949-B1 | Treating Type 2 diabetes, hyperglycemia, impaired glucose tolerance or obesity | NORO NORDISK A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078183-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | AKR1C3 1291/4885AKR1C2 1600/4885ALDH1A1 1111/4885 |
| US-20080227859-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | AKR1C3 1291/4885AKR1C2 1600/4885ALDH1A1 1111/4885 |
| US-20050203108-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | AKR1C3 2513/4885AKR1C2 1473/4885ALDH1A1 3968/4885 |
| US-20090143592-A1 | Glucagon Antagonists/Inverse Agonists | GLP1R, GPR119, GCGR | AKR1C3 2513/4885AKR1C2 1473/4885ALDH1A1 3968/4885 |
| US-20030220350-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | AKR1C3 2513/4885AKR1C2 1473/4885ALDH1A1 3968/4885 |
| US-20060235239-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | AKR1C3 1291/4885AKR1C2 1600/4885ALDH1A1 1111/4885 |
| US-20040209957-A1 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same | HTT, BDNF, APP | AKR1C3 1291/4885AKR1C2 1600/4885ALDH1A1 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.